英语翻译However,the preferred handling of peptides over protein faces challenges concerning the higher complexity of the proteome sample and the wider dynamic range,where thousands of peptides,with very similar m ass to charge (m/z) ratios,are pr

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英语翻译However,the preferred handling of peptides over protein faces challenges concerning the higher complexity of the proteome sample and the wider dynamic range,where thousands of peptides,with very similar m ass to charge (m/z) ratios,are pr

英语翻译However,the preferred handling of peptides over protein faces challenges concerning the higher complexity of the proteome sample and the wider dynamic range,where thousands of peptides,with very similar m ass to charge (m/z) ratios,are pr
英语翻译
However,the preferred handling of peptides over protein faces challenges concerning the higher complexity of the proteome sample and the wider dynamic range,where thousands of peptides,with very similar m ass to charge (m/z) ratios,are present at different levels of abundance.Considering that the human proteome (containing approximately 20,000 genes) yields millions of peptides,it becomes clear that this task is not a trivial exercise .Therefore,methods exhibiting high resolving power are required to maximize the separation of peptides before the m ass spectrometric analysis.Improved resolving power can help decrease competition between peptides during ionization and reduce the likelihood of ion sup-pression,increasing the possibility for the detection of low-abundance peptides (and the protein of origin).

英语翻译However,the preferred handling of peptides over protein faces challenges concerning the higher complexity of the proteome sample and the wider dynamic range,where thousands of peptides,with very similar m ass to charge (m/z) ratios,are pr
然而,肽的优先处理过的蛋白质组样品的蛋白质面临更复杂和更宽的动态范围的挑战,那里成千上万的肽,具有非常相似的质量电荷（的m / z）的比率,是目前在不同层次的丰富.考虑到人类蛋白质组（含约20000个基因）产生数以百万计的肽,它变得清晰,这是不是一个简单的运动任务.因此,具有高分辨率的方法需要最大限度的肽的分离前的质量光谱分析.改进的分辨率可以帮助减少竞争之间的肽在电离和减少离子支持压缩的可能性,提高低丰度肽检测的可能性（和起源的蛋白）.

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